AZORAN TABS

Description

Azoran Tablets are oral immunosuppressive medications containing Azathioprine, used for the management of autoimmune diseases and organ transplant rejection prevention. Azathioprine works by suppressing the immune system to prevent it from attacking the body’s own tissues or newly transplanted organs.

Common Uses:

• Prevention of organ rejection (e.g., kidney, liver transplants)

• Rheumatoid arthritis

• Systemic lupus erythematosus (SLE)

• Inflammatory bowel diseases (Crohn’s disease, ulcerative colitis)

• Autoimmune hepatitis

• Other autoimmune skin/muscle conditions (e.g., myasthenia gravis, dermatomyositis)

Mechanism of Action:

Azathioprine is converted into active metabolites that interfere with the synthesis of DNA and RNA in immune cells, reducing the proliferation of T- and B-lymphocytes, and thereby diminishing the immune response.

Dosage & Administration:

• Strengths available: 25 mg, 50 mg, 75 mg, 100 mg

• Typical dose: Varies by indication and patient body weight; usually taken once or twice daily

• Route: Oral

• Should be taken with food to minimize gastrointestinal side effects

Common Side Effects:

• Nausea, vomiting, diarrhea

• Fatigue

• Increased susceptibility to infections

• Liver enzyme changes

• Decreased blood cell counts (anemia, leukopenia, thrombocytopenia)

Monitoring Requirements:

• Regular CBC (complete blood count)

• Liver function tests (LFTs)

• Renal function monitoring

• Screening for infections like TB, hepatitis before starting therapy

Precautions:

• Avoid during pregnancy unless clearly necessary

• Do not take with allopurinol without dose adjustment (risk of toxicity)

• Live vaccines should be avoided during treatment

• May increase the risk of certain malignancies with long-term use

Brand Information:

• Brand: Azoran

• Generic Name: Azathioprine

• Manufacturer: RPG Life Sciences Ltd.